CELESTODERM-V WITH GARAMYCIN – has anti-inflammatory and anti-allergic effects, inhibits the release of cytokines and inflammatory mediators, reduces the metabolism of arachidonic acid, induces the formation of lipocortins, which have anti-edema activity, reduces vascular permeability.
Gentamicin is a broad-spectrum antibiotic that is effective against most common pathogens when used topically. Bacteria susceptible to gentamicin include sensitive strains of Streptococcus (beta-hemolytic, alpha-hemolytic), Staphylococcus aureus (coagulase-positive, coagulase-negative and some penicillinase-producing strains), and Gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, and Klebsiella pneumoniae.
Local treatment of skin diseases amenable to GCS therapy in the presence of secondary infection caused by gentamicin-susceptible microorganisms, or when such infection is suspected
The ointment is used for skin lesions against a background of eczema or psoriasis, and the cream is used for diseases of moist or oily skin.
Externally. Apply a thin layer on the affected areas of the skin 2 times a day – in the morning and in the evening.
Frequency of use other than recommended may be determined by a physician based on the severity of the disease. In mild cases once daily application is usually sufficient, in more severe lesions more frequent application may be necessary.
Local reactions: skin irritation (itching, erythema), burning sensation, dry skin, folliculitis, hypertrichosis, acne rash, hypopigmentation, perioral dermatitis, allergic contact dermatitis. When using occlusive dressings: skin maceration, secondary infection, skin atrophy, stretch marks, sweating.
With prolonged treatment or application to a large surface area: the development of systemic side effects typical for GCS is possible: weight gain, osteoporosis, increased blood pressure, edema, ulceration of mucous membranes of the gastrointestinal tract, worsening of latent foci of infection, hyperglycemia, agitation, insomnia, menstrual cycle disorders.
In children treated with local GCS the following side effects can be observed: suppression of hypothalamic-pituitary-adrenal system function, Cushing’s syndrome, stunting, delayed weight gain, increased intracranial pressure. Symptoms of suppressed adrenal cortex function in children include decreased plasma cortisol levels and no response to ACTH stimulation. Increased intracranial pressure is manifested by a swollen fontanelle, headache, and bilateral oedema of the optic disc.
Symptoms. Excessive or prolonged use of topical GCS may cause suppression of pituitary-adrenal function, which may cause development of secondary adrenal insufficiency and the appearance of symptoms of hypercorticism, including Cushing’s syndrome.
A single overdose of gemtamycin is not accompanied by any symptoms. Prolonged use in doses higher than recommended may cause significant growth of insensitive flora, including fungi, in the lesion area.
Treatment. Appropriate symptomatic treatment is indicated. Acute symptoms of hypercorticism are usually reversible. Correction of electrolyte imbalance is indicated, if necessary. In case of chronic toxicity, gradual withdrawal of GCS is recommended. In case of uncontrolled microbial growth, appropriate antibacterial or antifungal treatment should be selected.
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