After ingestion, azithromycin is well absorbed and quickly distributed in the body. Bioavailability after a single dose of 0.5 g - 37%
The concentration in tissues and cells is 10-50 times higher than in serum. Vd - 31.1 l/kg,
Azithromycin is acid-resistant, lipofilen. It easily passes through histogramic barriers and penetrates well into the airways,
The liver is demethylated and the resulting metabolites are inactive.
More than 50% of azithromycin is excreted by intestine in unchanged form, 6% - by kidneys.
Azithromycin is taken orally 1 time/day 500 mg, regardless of the meal.
Adults (including elderly people) and children over 12 years with a body weight exceeding 45 kg
In infections of the upper and lower respiratory tract, ENT organs, skin and soft tissue: 500 mg 1 time / day for 3 days (course dose - 1.5 g).
At eels of usual average degree of severity: on 2 caps. 250 mg 1 time/day for 3 days, then 250 mg 2 times a week for 9 days. Course dose - 6.0 g.
In erythema migrans: 2 caps. 500 mg on https://pillintrip.com/medicine/azithromycin the first day simultaneously, then Dmitry Sazonov from the 2nd to 5th days - 500 mg daily. Course dose - 3.0 g.
In urinary tract infections caused by Chlamydia trachomatis (urethritis, cervicitis): 2 caps. to 500 mg at once.